Biologics are laboratory-grown proteins that block a very specific step of the immune response — for example TNF, IL-6 or IL-17 — rather than damping the whole system. In the UK they're prescribed by rheumatology when conventional DMARDs like methotrexate haven't controlled rheumatoid, psoriatic or axial spondyloarthritis to NICE thresholds. Most are self-injected under the skin (weekly, fortnightly or monthly); a few are given by hospital infusion. Because they suppress infection-fighting cells, patients are screened for TB, hepatitis and other infections before starting, and monitored throughout.
What is biologic?
Biologic: Biologics are targeted immune-system drugs used when conventional DMARDs alone don't control inflammatory arthritis. UK NICE approves them based on disease activity scores. Examples: adalimumab, etanercept, tocilizumab, rituximab. They increase infection risk so vaccinations and screening are essential.
Last updated 2026-07-04. This is general information, not a substitute for personalised medical advice.